Determinants of Glaucoma Therapy Escalation After Descemet-Stripping Automated Endothelial Keratoplasty To Treat Pseudophakic Bullous Keratopathy: A Nested Case-Control Study

Purpose: To study the determinants of glaucoma therapy escalation (GTE) after Descemet-stripping automated endothelial keratoplasty (DSAEK) for pseudophakic bullous keratopathy in an eye-care hospital Saudi Arabia. Methods: This nested case-control evaluated patients who required medical or surgical treatment controlling DSAEK (defined as GTE; GTE group). A group did not require any intervention post-DSAEK served controls (control Data were collected on preoperative, intraoperative, and postoperative parameters DSAEK. Variables compared between groups to evaluate risk factors graft failure. Results: The sample comprised 117 eyes (40 77 control Glaucoma was present 20 (17.1%) before median duration follow-up 27 months [Interquartile range (IQR): 24; 42]. Intraoperative complications occurred 4 eyes, 2 had a decentered donor button. Graft failure causing vision impairment at final noted 19 (16.2%) 40 (34.2%) respectively. prior significantly associated with [odds ratio (OR) = 6.4; 95% confidence interval (CI) 2.4; 18.3; P 0.0004]. history penetrating (PK) [OR 6.2 (95% CI 1.5; 24.7) 0.008]. At last visit, positively (OR 27.2, < 0.005). Conclusion: Escalation warranted one 3 that undergone are interrelated complications. Patients PK have higher post-DSAEK.